Together, these steps allow for elegant experimental readouts to reliably assess the successful activation of the inflammasome complex and cell death.
Assembly of the inflammasome complex following infection or injury begins with the oligomerization of the upstream inflammasome-forming sensor and proceeds through a multistep process of well-coordinated events and downstream effector functions. Inflammasomes are multimeric heterogenous mega-Dalton protein complexes that play key roles in the host innate immune response to infection and sterile insults.
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